Faith, heresy and the cancer stem cell hypothesis

The Cancer Stem Cell Hypothesis in Oral Squamous Cell Carcinoma: A New Target for the Treatment

Within a single tumor clone, cells have significantly different abilities to proliferate and form new tumors. This has led to the hypothesis that most cells in a cancer have a limited ability to divide and only a small subset of distinct cells, the cancer stem cells (CSCs), has the capacity to self-renew and form new tumors . It has been proposed that the development of tumors is based exclusiv...

Modeling the Cancer Stem Cell Hypothesis

Solid tumors and hematological cancers contain small population of tumor cells that are believed to play a critical role in the development and progression of the disease. These cells, named Cancer Stem Cells (CSCs), have been found in leukemia, myeloma, breast, prostate, pancreas, colon, brain and lung cancers. It is also thought that CSCs drive the metastatic spread of cancer. The CSC compart...

the cancer stem cell hypothesis in oral squamous cell carcinoma: a new target for the treatment

within a single tumor clone, cells have significantly different abilities to proliferate and form new tumors. this has led to the hypothesis that most cells in a cancer have a limited ability to divide and only a small subset of distinct cells, the cancer stem cells (cscs), has the capacity to self-renew and form new tumors . it has been proposed that the development of tumors is based exclusiv...

The New Model of Carcinogenesis: The Cancer Stem Cell Hypothesis

Cancer has long been seen as a disease that arises from mutations and epigenetic alterations that impair the capacity of any cell within the organism to deregulation its proliferation, avoid apoptosis and metastasis, giving rise to malignant transformation. Progressively, these early cancer cells lead to different generations of daughter cells that accumulate additional mutations, acting in con...

Quantitative Approaches to the Cancer Stem Cell Hypothesis